2. Signaling Pathways
  3. GPCR/G Protein
  4. Prostaglandin Receptor

Prostaglandin Receptor

Prostaglandin Receptor

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Prostaglandin receptor, a sub-family of cell surface seven-transmembrane receptors, are the G-protein-coupled receptors. There are currently ten known prostaglandin receptors on various cell types. Prostaglandins bind to a subfamily of cell surface seven-transmembrane receptors, G-protein-coupled receptors. These receptors are named: DP1-2-DP1, DP2 receptors, EP1-4-EP1, EP2, EP3, EP4 receptors, FP-FP, IP1-2-IP1, IP2 receptors, TP-TP receptor. The prostaglandins are a group of hormone-like lipid compounds that are derived enzymatically from fatty acids and have important functions in the animalbody. There are currently ten known prostaglandin receptors on various cell types.

Prostaglandin Receptor Isoform Specific Products:

Prostaglandin Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-113350
    Thromboxane A2
    		Activator
    Thromboxane A2 (TXA2) is a prostanoid mediator produced by the metabolism of Arachidonic acid (HY-109590) through the cyclooxygenase pathway. Thromboxane A2 activates the thromboxane-prostanoid (TP) receptors. Thromboxane A2 is a potent vasoconstrictor eicosanoid. Thromboxane A2 (TXA2) leads to potent vasoconstriction by stimulation of smooth muscle cells. Thromboxane A2 acts as s tonic immunoregulator to regulate adaptive immune responses.
    Thromboxane A2
  • HY-130594
    6α-Prostaglandin I1
    6α-Prostaglandin I1 (6α-PGI1) is an analogue of prostacycline I2 (PGI2) and is resistant to hydrolysis in aqueous solution.
    6α-Prostaglandin I1
  • HY-165587
    BM-573
    		Modulator
    BM-573 is an orally active dual thromboxane A₂ (TXA₂) modulator with an IC50 of 1.3 nM. BM-573 possesses both thromboxane synthase (TxAS) inhibition and thromboxane receptor (TP) antagonistic effects. BM-573 can completely inhibit platelet aggregation induced by Arachidonic acid (HY-109590) or U-46619 (TXA₂ analogues). BM-573 completely blocks the generation of TXB₂ (the stable metabolite of TXA₂) in human platelets and does not inhibit cyclooxygenase (COX-1/COX-2), thus avoiding interference with other prostaglandin synthesis. BM-573 has an inhibitory effect on U-46619-induced contractions in rat gastric fundus smooth muscle (ED₅₀ = 4.2 μM), but has no effect on contractions caused by PGE₂, PGF₂α, or PGI₂. BM-573 can be used in the study of atherosclerosis, myocardial infarction, pulmonary hypertension and shock.
    BM-573
  • HY-116843
    (15S)-15-Methylprostaglandin E2
    		Agonist
    (15S)-15-Methylprostaglandin E2 ((15R)-15-Methyl-PGE) is a prostaglandin E2 analog with the potential to prevent gastrointestinal bleeding and protect gastrointestinal cells.
    (15S)-15-Methylprostaglandin E2
  • HY-B0131A
    Alprostadil sodium
    		Control
    Alprostadil sodium is a prostaglandin receptor ligand that exhibits Ki values of 36, 10, 1.1, 2.1, and 33 nM for the EP1, EP2, EP3, EP4, and IP receptors in mice, respectively. It promotes vasodilation and inhibits platelet aggregation, making it a useful vasodilator for investigating peripheral vascular disease.
    Alprostadil sodium
  • HY-163091
    EP4 receptor antagonist 5
    		Antagonist
    EP4 receptor antagonist 5 is a potent and selective prostanoid EP4 receptor antagonist that can reduce inflammation Freund’s adjuvant (CFA) model.
    EP4 receptor antagonist 5
  • HY-117953
    RU 59063
    		Inhibitor
    RU 59063 is an N-substituted arylthiohydantoin compound with antiandrogenic activity and high relative binding affinity for the rat androgen receptor. RU 59063 is a nonsteroidal androgen receptor that functions as a radioactive AR radioprobe (Ki: 0.71 nM, rAR) when its trifluoromethyl group is replaced by a similar hydrophobic iodine atom.
    RU 59063
  • HY-B0191S1
    Bimatoprost-d4
    		Agonist
    Bimatoprost-d4 is the deuterium labeled Bimatoprost. Bimatoprost is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension.
    Bimatoprost-d<sub>4</sub>
  • HY-125946
    Latanoprost lactone diol
    		99.86%
    Latanoprost lactone diol is an intermediate in the synthesis of Latanoprost. Latanoprost is a prostaglandin F2α analogue and an agonist for the FP prostanoid receptor, and lowers intraocular-pressure (IOP).
    Latanoprost lactone diol
  • HY-121091
    EP2 receptor agonist 4
    		Agonist
    EP2 receptor agonist 4 is a selective agonist for EP2 receptor with an EC50 of 43 nM.
    EP2 receptor agonist 4
  • HY-W746807
    Bimatoprost cyclohexyl amide
    		Agonist
    Bimatoprost cyclohexyl amide (N-Cyclohexyl-desamethyl bimatoprost; 17-Phenyl trinor prostaglandin F2α cyclohexyl amide) is an analog of bimatoprost (HY-B0191). Bimatoprost cyclohexyl amide is an agonist of the prostaglandin F2α receptor. Bimatoprost cyclohexyl amide is used in research on reducing intraocular pressure and glaucoma.
    Bimatoprost cyclohexyl amide
  • HY-19755
    S-5751
    		Antagonist
    S-5751 is an orally active prostaglandin DP receptor antagonist. S-5751 inhibits cAMP generation in platelet-rich plasma induced by PGD2 with IC50 0.12 μM. S-5751 has anti-inflammatory activity. S-5751 can be used in asthma research.
    S-5751
  • HY-B0191A
    5,6-trans-Bimatoprost
    		Control
    5,6-trans-Bimatoprost is the isomer of Bimatoprost (HY-B0191), and can be used as an experimental control. Bimatoprost is a prostaglandin analogue that can be used in studies of ocular hypertension and glaucoma and also has anti-fat formation effects.
    5,6-trans-Bimatoprost
  • HY-116051
    16,16-Dimethylprostaglandin F2α
    16,16-Dimethylprostaglandin F2α (16,16-Dimethyl-PGF2α) is a potent analog of PGF2α (HY-12956), which exhibits similar binding potency as PGF2α does. 16,16-Dimethylprostaglandin F2α serves as a bronchoconstrictor.
    16,16-Dimethylprostaglandin F2α
  • HY-116250
    Prostaglandin D2-1-glyceryl ester
    		Agonist
    Prostaglandin D2-1-glyceryl ester (PGD2-G; PGD2 2-glyceryl ester).
    Prostaglandin D2-1-glyceryl ester
  • HY-108564
    L 655240
    		Antagonist
    L 655240 is thromboxane antagonist. L 655240 attenuates early ischemia- and reperfusion-induced arrhythmias in a canine model of coronary artery occlusion. L 655240 also involves in cancer and autoimmune disorders.
    L 655240
  • HY-19641
    AH13205
    		Agonist
    AH13205 is a selective prostanoid EP2-receptor agonist. AH13205 causes concentration-related relaxations of Carbachol (HY-B1208)-contracted trachea. AH13205 causes dose-related protection against Histamine (HY-B1204)-induced increases in respiratory rate.
    AH13205
  • HY-169803
    L-657926
    L-657926 is a stereoselective antagonist of the thromboxane A2 (TxA2) receptor, composed of (-)-9-chlorobenzyl-6-fluoro-1,2,3,4-tetrahydrocarbazol-1-yl acetic acid and (+)-9-chlorobenzyl-6-fluoro-1,2,3,4-tetrahydrocarbazol-l-yl acetic acid. The IC50s of (-) and (+) configurations for TxA2 are 0.27 nM and 124 nM, respectively.
    L-657926
  • HY-118163
    tetranor-PGFM
    		Control
    tetranor-PGFM is the major urinary metabolite of Dinoprost (HY-12956).
    tetranor-PGFM
  • HY-137574
    19(R)-Hydroxy prostaglandin E1
    		Agonist
    19(R)-Hydroxy prostaglandin E1 (19(R)-Hydroxy PGE1), the major prostaglandin in primate semen, is an agonist of EP1 and EP3 receptor subtypes and exhibits contractile activity on smooth muscle preparations.
    19(R)-Hydroxy prostaglandin E1
Cat. No. Product Name / Synonyms Application Reactivity
Prostaglandin Receptor Isoform Comparison

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